Cost-effectiveness analysis of OM-85 vs placebo in the prevention of acute respiratory tract infections (ARTIs) in children that attend day-care centers

Table 3 Probabilities of ARTIs in 2–6 year-old children at day-care centers or preschools and estimated costs, for use in the bootstrap method estimated by the expert panel

Event	Range
≥6 ARTIs/y	0.50–0.80
6–10 ARTIs/y	0.80–0.90
11–12 ARTIs/y	0.10–0.20
6 ARTIs/y	0.05–0.10
7 ARTIs/y	0.36–0.44
8 ARTIs/y	0.30–0.50
9 ARTIs/y	0.36–0.44
10 ARTIs/y	0.05–0.10
11 ARTIs/y	0.40–0.60
12 ARTIs/y	0.40–0.60
ARTIs in Fall-Winter Season	0.60–0.70
Simple acute lower ARTIs	0.01–0.02
Simple acute upper ARTIs	0.70–0.80
Acute otitis media	0.13–0.25
Acute rhinosinusitis	0.03–0.07
Tx with antibiotics for simple acute lower ARTIs	1
Tx without antibiotics for simple acute upper ARTIs	0.30–0.40
Tx with antibiotics for simple acute upper ARTIs	0.60–0.70
Tx without antibiotics for acute otitis media	0.20–0.30
Tx with antibiotics for acute otitis media	0.70–0.80
Tx without antibiotics for acute rhinosinusitis	0.10–0.20
Tx with antibiotics for acute rhinosinusitis	0.80–0.90
Cost of Tx without antibiotics ($MXN)	95–1450
Cost of Tx with antibiotics ($MXN)	157–2491
Cost of parent job absenteeism ($MXN)	630–2100
OM-85 effectiveness (ARTI reduction)	0.38–0.55
Cost of OM-85 ($MXN)	258–430
Cost of OM-85 adverse events ($MXN)	11.1–22.2

Values are frequencies, unless otherwise indicated. ARTI acute respiratory tract infection, Tx treatment

ISSN: 2191-1991